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Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. Within just only a few months, we were being capable of evaluate transport through someone single-walled carbon nanotube. Determined by reduced-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Lively study lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were authentic quantum wires with extremely very long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic behaviour.
Experimental period diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
MATLAB codes for data processing are offered at . Julia codes utilized for numerical simulation are available at .
2000, discovery that nanotubes can carry remarkable substantial present densities; solved the controversial issue of electronic transportation as a result of DNA molecules by measurements of insulating conduct at The only molecule amount; and demonstration of an AFM procedure for one-molecule manipulation of nanotubes
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There was a person problem although — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been essentially not these types of great conductors, which was fairly disappointing. We Hence broadened our look at to test to uncover extra promising https://www.ceesdekker.net molecules.
In 1993 he was appointed as Associate Professor at Delft University of Know-how. In the mid-nineties Dekker and his workforce accomplished results with the invention from the Digital Attributes of carbon nanotubes, the initial solitary-molecule transistor and various nanoscience.
Numerous new phenomena were being uncovered, and he and his study team set up a number one place During this subject of study. Dekker and his investigate group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor dependant on an individual nanotube molecule.
As an example, we look at the nucleopore complex, a gateway concerning the mobile nucleus as well as the cytoplasm. This is a very sophisticated technique and thus difficult to analyze in the cell, so we use biomimetics. We reconstruct holes after which you can insert particular person factors from the nucleopore elaborate to review transport by it at the single-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij achieved enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style and design in 2005. (nl)